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Cognitive-Behavior Therapy for Young Adults With Bipolar Disorder.
Interventional study. The aim of the study is to develop and pilot test a cognitive-behavioral (CBT) intervention for young adults, ages 18-24 with bipolar disorder. Ages 18-24. Location in Boston, MA.
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Sleep Disturbance and Bipolar Disorder.
Interventional study. The study aims to evaluate a psychological intervention for individuals who suffer from sleep disturbance and bipolar disorder. Ages 18 and over. Location in Berkeley, CA.
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Prevention of Relapse & Recurrence of Bipolar Depression.
Interventional study. The purpose of this study is to determine whether the long-term use of combined antidepressant plus mood stabilizer therapy is superior to mood stabilizer therapy alone in preventing the relapse and recurrence of bipolar depression. Ages 18 and over. Locations in Chicago, IL; Philadelphia, PA.
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Pediatric Bipolar Disorder Study at UCLA.
Evaluation study. The UCLA Semel Institute for Neuroscience in Los Angeles, CA, is conducting a study looking at similarities and differences in how the brain works between bipolar disorder and attention deficit hyperactivity disorder (ADHD). Ages 7-17. Location in Los Angeles, CA.
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Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder.
Interventional study. This study will test a family-based therapy aimed at preventing or reducing the symptoms of bipolar disorder in at-risk children. Ages 9-17. Locations in Stanford, CA; Boulder, CO.
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Using Cognitive Training to Improve Employment Programs for People With Severe Mental Illnesses.
Interventional study. This study will compare the efficacy of two types of supportive treatments for a program called Individual Placement and Support, which helps people with severe mental illnesses find and keep jobs. Ages 18 and over. Location in San Diego, CA.
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Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder.
Interventional study. Pediatric Bipolar Disorder (BD) is uncommon in children. Ages 9-17. Location in Bethesda, MD.
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Adapting the Bipolar Care Model for Chronic Care Management in Community-based Health Care Sites.
Interventional study. This study will determine if a version of the bipolar care model adapted for a nonresearch audience can improve patient health and correct use of the model in community-based mental health care sites. Ages 18 and over. Locations in Denver, CO; Ann Arbor, MI.
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Efficacy and Safety of Galantamine for Improving Dysfunction in People With Bipolar Disorder.
Interventional study. This study will examine whether extended release galantamine, a drug approved by the Food and Drug Administration to reduce cognitive impairments in people with Alzheimer's disease, can perform the same function in stable people with bipolar disorder. Ages 18-65. Locations in Boston, MA; New York, NY.
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Identifying Predictors of Bipolar Disorder Relapse During Pregnancy and the Postpartum Period.
Evaluation study. This study will evaluate pregnant women who have bipolar disorder to gain a better understanding of risk factors for bipolar disorder relapse during pregnancy and the postpartum period. Ages 18-45. Location in Atlanta, GA.
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Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.
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FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder.
Interventional study. This study will assess the effects of bipolar disorder on brain activity and will determine if medication changes the brain activity in people with bipolar disorder. Ages 18-60. Location in Indianapolis, IN.
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Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder.
Interventional study. This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder. Ages 18-64. Location in Boston, MA.
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Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses.
Interventional study. This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses. Ages 18-70. Location in Baltimore, MD.
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Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders.
Evaluation study. This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Ages 18-50. Location in Bethesda, MD.
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Measuring Smoking Behavior in People With Schizophrenia and Bipolar Disorder.
Evaluation study. This study will evaluate the differences in smoking behavior, nicotine intake, and nicotine boost among people with schizophrenia, bipolar disorder, or no mental illness. Ages 18-75. Location in New Brunswick, NJ.
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The Antidepressant Efficacy of the Anticholinergic Scopolamine.
Interventional study. A previous study showed that the intravenous administration of scopoalmine produces antidepressant effects. Ages 18-55. Location in Bethesda, MD.
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Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.
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Effectiveness of Family-Focused Treatment Plus Pharmacotherapy for Bipolar Disorder in Adolescents.
Interventional study. This study will evaluate the effectiveness of family-focused treatment (FFT) plus pharmacotherapy in treating adolescents with bipolar disorder. Ages 13-17. Locations in Boulder, CO; Cincinnati, OH; Pittsburgh, PA.
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Impact of Pregnancy and the Postpartum Period on Women With Bipolar Disorder.
Evaluation study. This study will determine the risk factors for a depressive, manic, or hypomanic episode during pregnancy and the postpartum period in women with bipolar disorder. Ages 18-45. Location in Boston, MA.
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Bipolar II Depression: Lithium, SSRI, or the Combination.
Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Palo Alto, CA; Mason, OH.
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Treatment of Bipolar Mania in Older Adults.
Interventional study. This study will compare the benefits and side effects of lithium and divalproex in the treatment of older adults with bipolar mania. Ages 60 and over. Locations in Flowood, MS; White Plains, NY; Durham, NC; Cleveland, OH; Philadelphia, PA; Pittsburgh, PA; Houston, TX; Toronto, Canada.
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Treatment of Mania Symptoms With Drug Therapy.
Interventional study. This study will determine the effectiveness of three different drug therapies in treating the symptoms of mania. Ages 18-65. Location in Palo Alto, CA.
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Rapid Antidepressant Effects of Ketamine in Major Depression.
Interventional study. This study examines whether Ketamine can cause a rapid-next day antidepressant effect in patients with Major Depression/Bipolar Disorder . Ages 18-65. Location in Bethesda, MD.
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Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies.
Interventional study. This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.... Ages 18-55. Location in Bethesda, MD.
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Riluzole to Treat Depression in Bipolar Disorder.
Interventional study. This study examines if Riluzole, (FDA approved for ALS), will improve symptoms of depression in Bipolar Disorder. Ages 18-70. Location in Bethesda, MD.
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Examination of Brain Serotonin Receptors in Patients With Mood Disorders.
Evaluation study. The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. Ages 18-60. Location in Bethesda, MD.
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Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder.
Evaluation study. We study the course of child bipolar illness and how brain function differs between youth with bipolar disorder, those 'at-risk,' and healthy volunteers. Ages 7-17. Location in Bethesda, MD.
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Child & Adolescent Bipolar Disorder Brain Imaging and Treatment Study.
Evaluation study. The National Institute of Mental Health is seeking boys and girls ages 6 to 17 with bipolar disorder who are not doing well on their current medication(s) to participate in a research study. Ages 3-17. Location in Washington, DC.
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Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers.
Evaluation study. The purpose of this study is to use brain imaging technology to compare differences in brain structure, chemistry, and functioning in individuals with brain and mental disorders compared to healthy volunteers. Ages 18 and over. Location in Bethesda, MD.
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Brain Tissue Collection for Neuropathological Studies.
Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.
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Evaluation of the Genetics of Bipolar Disorder.
Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18 and over. Location in Bethesda, MD.
Search ClinicalTrials.gov for other NIH studies on Bipolar Disorder (Manic-Depressive Illness).
